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| Part of a series on |
| Toxicology and poison |
|---|
| Toxicology (Forensic) · Toxinology History of poison (ICD-10 T36-T65, ICD-9 960-989) |
| Concepts |
| Poison · Venom · Toxicant (Toxin) · Antidote Acceptable daily intake · Acute toxicity Bioaccumulation · Biomagnification Fixed Dose Procedure · LD50 · Lethal dose Toxic capacity · Toxicity Class |
| Toxins and venoms |
| Neurotoxin · Necrotoxin · Hemotoxin Mycotoxin · Aflatoxin · Phototoxin List of fictional toxins |
| Incidents |
| Bradford · Minamata · Niigata Alexander Litvinenko · Bhopal 2007 pet food recalls List of poisonings |
| Poisoning types |
| Elements Toxic metal (Lead · Mercury · Cadmium · Antimony · Arsenic · Beryllium · Iron · Thallium) · Fluoride · Oxygen Seafood Shellfish (Paralytic · Diarrheal Amnesic) · Ciguatera · Scombroid Tetrodotoxin Other substances Pesticide · Organophosphate · Food Nicotine · Theobromine · Carbon monoxide · Vitamin · Medicines Living organisms Mushrooms · Plants · Venomous animals |
| Related topics |
| Hazard symbol · Carcinogen Mutagen · List of Extremely Hazardous Substances · Biological warfare · Food safety |
In toxicology, the median lethal dose, LD50 (abbreviation for “Lethal Dose, 50%”), or LCt50 (Lethal Concentration & Time) of a toxic substance or radiation is the dose required to kill half the members of a tested population. LD50 figures are frequently used as a general indicator of a substance's acute toxicity. The test was created by J.W. Trevan in 1927. It is being phased out in some jurisdictions in favor of tests such as the Fixed Dose Procedure, however the concept, and calculation of the median lethal dose for comparison purposes, continues in wide use. As a measure of toxicity, LD50 is somewhat unreliable and results may vary greatly between testing facilities due to factors such as the genetic characteristics of the sample population, environmental factors and mode of administration.
The term semilethal dose is occasionally used with the same meaning, particularly in translations from non-English-language texts, but can also refer to a sublethal dose; because of this ambiguity, it is usually avoided.
topA lethal dose (LD) is an indication of the lethality of a given substance or type of radiation. Because resistance varies from one individual to another, the 'lethal dose ...
In toxicology, the median lethal dose, LD 50 (abbreviation for “Lethal Dose, 50%”), or LCt 50 (Lethal Concentration & Time) of a toxic substance or radiation is the dose ...
Directed by Simon De Selva. With Katharine Towne, Melanie Brown, Tom Hardy. Visit IMDb for Photos, Showtimes, Cast, Crew, Reviews, Plot Summary, Comments, Discussions, Taglines ...
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Lethal Dose (Sung to the tune of "Gallows Pole" by Led Zeppelin) Guest song parody by Skisics Surus, skisics@yahoo.com